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Kinase-Glo® Luminescent Kinase Assays
产品名称： Kinase-Glo® Luminescent Kinase Assays
型号：
时间： 2017 - 01 - 25
Kinase-Glo® Luminescent Kinase Assay 10ml V6711Kinase-Glo® Luminescent Kinase Assay 10 × 10ml V6712Kinase-Glo® Luminescent Kinase Assay 100ml V6713Kinase-Glo® Luminescent Kinase Assay 10 × 100ml V6714Kinase-Glo® Max Luminescent Kinase Assay 10ml V6071Kinase-Glo® Max Luminescent Kinase Assay 10 × 10ml V6072Kinase-Glo® Max Luminescent Kinase Assay 100ml V6073Kinase-Glo® Max Luminescent Kinase Assay 10 × 100ml V6074Kinase-Glo® Plus Lu...
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EGFR Kinase Enzyme System
产品名称： EGFR Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
EGFR Kinase Enzyme System 10μg V3831EGFR Kinase Enzyme System 1mg V3832ADP-Glo™ Kinase Assay + EGFR Kinase Enzyme System 1 each V9261 EGFR 的激活会刺激胃肠粘膜中有丝分裂的信号转导；在结肠癌和多数肿瘤中，EGFR 的表达会上调。在正常的胃上皮和结肠癌细胞系中，EGFR 的激活会引发ERK 信号途径的激活。用选择性抑制剂使EGFR 失活后，ERK2 活性、c-fos mRNA 的表达、及细胞增殖都显著降低。ADP-Glo™ Kinase Assay（ADP-Glo™ 激酶检测试剂盒）是一种发光法激酶检测试剂盒，用于 检测 激酶反应产生的ADP 含量：ADP 转化为ATP 后，ATP 即可作为Ultra-Glo™ 萤光素酶 催化反应的底物，产生光信号。发光信号与 ADP 的量和激酶活性正相关。 该试剂盒适合检测化合物对纯化的多种激酶活性的影响，使之成为初筛和激酶选择性概况分析的理想工具。ADP-Glo™ 激酶检测试剂盒可用于检测几乎所有可生成...
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FGFR2 Kinase Enzyme System
产品名称： FGFR2 Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
FGFR2 Kinase Enzyme System 10μg V4060FGFR2 Kinase Enzyme System 1mg V6392ADP-Glo™ Kinase Assay + FGFR2 Kinase Enzyme System 1 each V4061 FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis (1). FGFR2 is required for early postimplantation development between impl...
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FGFR4 Kinase Enzyme System
产品名称： FGFR4 Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
FGFR4 Kinase Enzyme System 10μg V4062FGFR4 Kinase Enzyme System 1mg V6393ADP-Glo™ Kinase Assay + FGFR4 Kinase Enzyme System 1 each V4063 FGFR4 preferentially binds acidic fibroblast growth factor and is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4 gene expression is upregulated in doxorubicin-treated, apoptosis-resistant cancer cell clones (2). Ectopic expression of FGFR4 in cancer cells leads to reduced apoptosis sensitivity...
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CDK9/CyclinK Kinase Enzyme System
产品名称： CDK9/CyclinK Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
CDK9/CyclinK Kinase Enzyme System 10μg V4104CDK9/CyclinK Kinase Enzyme System 1mg V6283ADP-Glo™ Kinase Assay + CDK9/CyclinK Kinase Enzyme System 1 each V4105 CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat...
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CDK2/CyclinE1 Kinase Enzyme System
产品名称： CDK2/CyclinE1 Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
CDK2/CyclinE1 Kinase Enzyme System 10μg V4488CDK2/CyclinE1 Kinase Enzyme System 1mg V6280ADP-Glo™ Kinase Assay + CDK2/CyclinE1 Kinase Enzyme System 1 each V4489 CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (...
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EGFR (T790M) Kinase Enzyme System
产品名称： EGFR (T790M) Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
EGFR (T790M) Kinase Enzyme System 10μg V4506EGFR (T790M) Kinase Enzyme System 1mg V6583ADP-Glo™ Kinase Assay + EGFR (T790M) Kinase Enzyme System 1 each V4507 Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Act...
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CDK6/CyclinD3 Kinase Enzyme System
产品名称： CDK6/CyclinD3 Kinase Enzyme System
型号：
时间： 2017 - 01 - 25
CDK6/CyclinD3 Kinase Enzyme System 10μg V4510CDK6/CyclinD3 Kinase Enzyme System 1mg V6282ADP-Glo™ Kinase Assay + CDK6/CyclinD3 Kinase Enzyme System 1 each V4511  CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors (1). The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the ...
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